ICBET 2019          Full Paper Submission Deadline: 25 January 2019     Conference Dates: 28th - 30th March 2019      Conference Place: Tokyo, Japan



Meiji University, Tokyo, Japan




Keynote Speaker I

Prof. Chiharu Ishii
Hosei University, Japan

Chiharu Ishii received his PhD in Mechanical Engineering from Sophia University, Japan in 1997. From 2002 to 2009, he was an Assistant Professor with Kogakuin University. Currently, he is a Professor at the Department of Mechanical Engineering, Hosei University, Japan. He has received several awards such as The Best Paper Award in the area of Tactile and Haptic Interfaces at the 4th International Conference on Human System Interaction (HSI 2011); Best Paper Award at the 1st International Conference on Computer Science, Electronics and Instrumentation (ICCSE 2012); Best Presentation Award at the International Conference on Intelligent Mechatronics and Automation (ICIMA 2013); Excellent Oral Presentation Award, at the 4th International Conference on Soft Computing & Machine Intelligence (ISCMI 2017). He is currently a member of IEEE, SICE, JSME, RSJ, IEEJ and JSCAS. His research interests are in medical robotics, assistive technology and robust control.

Speech Title: "Current Trends on Development of Medical and Assistive Devices"

Abstract: Japan is facing a serious problem of population aging. The percentage of elderly people of age 65 years or over (aging ratio) was 27.3% in 2017, and it is forecasted that the aging ratio becomes 33.4% in 2035. In this way, Japan has reached a super-aged society which no country in the world has experienced. Becoming the super-aged society, it is necessary to respond to the demand of medical care and nursing of elderly people. Therefore, challenge for development of medical and assistive devices through an application of the Robot Technology (RT) has been promoted. In this talk, some medical and assistive devices developed in my laboratory are introduced.
The robotic surgical system for single-port-surgery termed “HASROSS”, the lightweight power assist suit termed “Cool Vest” to reduce caregiver’s lumbar burden, the ultra-lightweight power assist suit termed “Aero back” to support workers who are working in half-sitting posture, control system of the electric wheelchair based on user’s biosignals such as EMG, EOG and EEG, and sensory feedback device for myoelectric prosthetic hand, are explained.

Keynote Speaker II

Prof. Tjokorda Gde Tirta Nindhia
Udayana University, Indonesia

Tjokorda Gde Tirta Nindhia received Doctor Degree from Gadjah Mada University (UGM) Yogyakarta, Indonesia on August 2003, with major field of study was Material Engineering. He participated in various international research collaborations such as with Muroran Institute of Technology Japan (2004), Toyohashi University of Technology Japan (2006), Leoben Mining University Austria (2008-2009), Technical University of Vienna Austria (2010), Institute Chemical technology of Prague Czech Republic (2012-now) and very recently with Michigan State University (MSU) and University of Hawaii in the USA under Fulbright Scholarship. His current job is as Full Professor in the field of Material Engineering at Engineering Faculty, Udayana University, Jimbaran, Bali, Indonesia. His research interest covers subjects such as, Biomedical Engineering, biosensor, biomaterial, waste recycle, failure analyses, advance ceramic, metallurgy, composite, renewable energy, and environmental friendly manufacturing.Speech Title: "STAT3 as a Molecular Target for Cancer Therapy".

Speech Title: "Biocompatibility and Tensile Strength of Natural Silk Fibers: Bombyx mori, Cricula trifenestrata and Attacus atlas"

Abstract: Three types of silk fiber obtained from silkworm cocoon from 3 diferent species of silkworm cocoon namely: Bombix mory, Cricula trifenestrata and Attacus atlas were investigated in this research. The biocompatibility and tensile strength will be investigate and compared for future consideration in application as biomaterial. Bombyx mori silk is well known and obtained from domesticated silkworm cocoon of Bombyx mori. It is biocompatible as biomaterial and has been used commercially as sutures in biomedical. Bombyx mori silkworm eat only one (monophagous) type of leaf (leaf of mulberry plant). Both Cricula trifenestrata and Attacus atlas are wild silkmoth and fiber can be obtained from its cocoon. Cricula trifenestrata and Attacus atlas are wild (non domesticated) and eat variety of leaf plant in their development. It can be concluded that the silk obtained from cocoon of Cricula trifenestrata has best biocompatibility properties followed by Attacus atlas and after that Bombyx mori. The highest tensile test is found for Bombix mori (230 MPa) followed by Attacus atlas (101 MPa) and the lowest is Cricula trifenestrata (162 MPa).

Keynote Speaker III

Prof. Carmine Pappalettere
Politecnico di Bari, Italy

Carmine Pappalettere is full professor of “Mechanical Engineering and Experimental Mechanics”, Dipartimento di Meccanica, Matematica e Management – DMMM (Mechanical Design Division), Politecnico di Bari (PoliBa). He got the Master degree in Mechanical Engineering, Università degli Studi di Bari in 1975 and worked as Head of the Dept. (2000-2004), Coordinator of Ph.D. courses in Mechanical and Biomechanical Design (2004-2009). He teaches classes such as Aerospace design, Design of machines, Design of ground vehicles, Experimental stress analysis. He published more than 400 papers in international journals, edited books and conferences proceedings. 178 papers are counted on Scopus, with a total number of 1656 citations for a h-index of 24.

Speech Title: "Optical Methods Applied to Bioengineering: Examples of Applications at Politecnico di Bari"

Abstract: Optical Methods constitute a broad class of experimental techniques widely used in many fields of experimental mechanics to measure displacements and/or strains and/or stresses. Independently of the specific working principle of each technique (Moiré, Speckle Interferometry, Photoelasticity etc.) all of them share some common features: they are not contact, not invasive, high resolution and high sensitivity techniques, depending from the particular application. All these aspects make these methods appealing for applications in bioengineering problems. This paper will present on overview of successful applications of optical methods to several different problems as performed during more than 40 years of research on this topic in the Experimental Mechanics Laboratory of Politecnico di Bari. The most recent results will be in particular showed, such as the application of the fringe projection methods to endoral 3D teeth reconstruction, the mechanical characterization of umbilical cord by moiré methods, the mechanical behavior of bovine bones by means of PS-ESPI (Phase Shifting Electronic Speckle Pattern Interferometry).

Plenary Speaker I

Prof. Robert Borris
Tianjin University, China

Following completion of a BS degree (Biology) from Loyola University in Chicago, Robert P. Borris earned his BS (Pharmacy) and PhD (Pharmacognosy) degrees at the University of Illinois Medical Center in Chicago. He then pursued postdoctoral studies in organic chemistry at the University of Zurich (Switzerland). Returning to the United States, he served as an Assistant Professor of Pharmacognosy at Rutgers University before moving to the pharmaceutical industry where he established and headed phytochemical research in the New Drug Discovery programs at Merck Research Laboratories. Retiring after a long career at Merck, he became Vice President for Botanical Science and Regulation at the Council for Responsible Nutrition (Washington DC) before moving to the University of Hawaii at Hilo as Associate Dean for Research at the newly formed Daniel K. Inouye College of Pharmacy. After seven years in Hawaii, he moved to his current position of Professor and Vice Dean (Research and Academic Programs) at the School of Pharmaceutical Science and Technology, Health Sciences Platform, at Tianjin University. Throughout his career, his passion for “Discovery” in general and “Natural Products Chemistry” in particular have enabled him to become President of the American Society of Pharmacognosy (1997-8) and a Fellow of the Linnean Society of London. Research in the Borris Laboratory focuses on the isolation and structure elucidation of naturally occurring compounds with biological activity and/or taxonomic significance, including the general theme of exploring the disconnect between traditional medicine and Western medical science.

Speech Title: "Back to the Future: Exploring the Disconnect Between Traditional Chinese Medicine and Western Medical Science"

Abstract: The World Health Organization (WHO) has stated that the majority of people worldwide rely on some form of traditional medicine to address their medical needs. Some of these traditional practices, including Traditional Chinese Medicine (TCM) for example, have been used, documented and refined over the space of thousands of years. Efficacy is well documented and often undeniable. Nonetheless, many published and unpublished investigations in Western laboratories have failed to detect and/or isolate the chemical principles that are responsible for the observed biological activities in man. The inability of Western science to ‘validate’ the efficacy of TCM in the laboratory has contributed to the skepticism about traditional medicine that is prevalent throughout much of the “Developed World”, severely limiting the acceptance of TCM outside of China. The present study explores some potential reasons for the apparent disconnect between the observed clinical efficacy of TCM and the disappointing results in laboratory studies.

Plenary Speaker II

Assoc. Prof. Keimei Oh
Akita Prefectural University, Japan

Dr. Keimei Oh was born in Shanghai, China. He received B.Sc. in the Department of Chemistry from Shanghai University and Ph.D. degree from the Graduate School of Agricultural and Life Sciences, The University of Tokyo in 1997. After working at RIKEN as a Special Postdoctoral Fellow, he joined the Department of Biotechnology faculty at Akita Prefectural University in 1999. In 2003, he worked as a visiting scientist at US Department of Energy, Plant Research Laboratory in Michigan State University. He was appointed as Associate Professor at Akita Prefectural University in 2007. Currently, he is working in the field of design and synthesis biological active chemicals targeting plant hormone biosynthesis and signaling transduction pathways. He received numerous awards including the Society Award of the Japanese Society for Chemical Regulation of Plants.

Speech Title: "A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis"

Abstract:  Chemical genetics is an effective way to discover new biological active compounds. The process is based on the phenotypic screening of compound libraries through searching chemicals that are able to induce phenotypes of interests. In the present study, report the discovery of new compound that induce “triple response” in Arabidopsis Among 9600 compound, we found a compound with pyrazole moiety (EH-1) exhibited promising activity to induce triple response in Arabidopsis seeding. To determine the action mechanism of EH-1, insensitive mutants of ethylene signaling were used. Also, we carried out RNA sequencing (RNA-seq) analysis.
Acknowledgement: This research is supported by JSPS KAKENHI Grant Number 16K01936 to Keimei Oh and is partially supported by the Platform Project for Supporting in Drug Discovery and Life Science Research(Platform for Drug Discovery, Informatics, and Structural Life Science)from Japan Agency for Medical Research and Development (AMED).

Invited Speaker I

Assoc. Prof. Md. Altaf-Ul-Amin
Nara Institute of Science and Technology, Japan

Md. Altaf-Ul-Amin received B.Sc. degree in Electrical and Electronic Engineering from Bangladesh University of Engineering and Technology (BUET), Dhaka, M.Sc. degree in Electrical, Electronic and Systems Engineering from Universiti Kebangsaan Malaysia (UKM) and PhD degree from Nara Institute of Science and Technology (NAIST), Japan. He received the best student paper award in the IEEE 10th Asian Test Symposium. Also, he received two other best paper awards as a co-author of journal articles. He previously worked in several universities in Bangladesh, Malaysia and Japan. Currently he is working as an associate professor in Computational Systems Biology Lab of NAIST. He is conducting research on Network Biology, Systems Biology, Cheminformatics and Biological Databases. He published around 60 peer reviewed papers in international journals and conference proceedings. Google scholar citation index of his publications is currently more than 4700.

Speech Title: "Applications of KNApSAcK Database and DPClus Algorithm: Plants to Metabolites to Target Proteins in the Context of Jamu Medicines and IBD Gene Prediction"

Abstract: Initially, we developed KNApSAcK as a species-metabolite relational database and subsequently, inspired by its popularity we extended it to KNApSAcK family databases by adding different types of omics data together with data regarding edible plants and traditional medicines mainly focusing human health care and ecology. Previously we also developed graph clustering algorithms DPClus and DPClusO, which we and many other researchers applied to analysis of versatile omics data. In the present talk, first, I will briefly focus on the KNApSAcK database and the DPClus algorithm. Then I will discuss a new method to predict the relation between plant and disease using network analysis and supervised clustering based on Jamu formulas. Next, I will extend the talk on the analysis for predicting Jamu efficacy based on metabolite composition and identifying important metabolites. I will then focus on prediction of target proteins by Jamu metabolites. Finally, I will discuss application of DPClusO algorithm in finding inflammatory bowel disease related genes.




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